|(1alpha,3R,4alpha,5R)-4-[[3-(3,4-二羟基苯基)-1-氧代-2-丙烯-1-基]氧基]-1,3,5-三羟基环己烷羧酸|CsnPharm

CAS No.: 905-99-7

隐绿原酸 Catalog No. CSN16249

Synonyms: 4-Caffeoylquinic acid;4-O-Caffeoylquinic acid;隐绿原酸

Cryptochlorogenic acid is a natural product isolated and purified from the flowerbud of Lonicera japonica Thunb. showing antioxidant activity.

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400-920-2911

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技术信息

生物活性

描述Cryptochlorogenic acid is a natural product isolated and purified from the flowerbud of Lonicera japonica Thunb, showing antioxidant activity. The blood glucose level, iron content, accumulation of lipid peroxides and islet injury in diabetic model were all improved by CCA (Cryptochlorogenic Acid) via a concentration-dependent manner. CCA functions via inhibition of ferroptosis by activation of cystine/glutamate transporter system (XC-)/glutathione peroxidase 4(GPX4)/Nrf2 and inhibition of nuclear receptor coactivator 4 (NCOA4) in diabetes^[3]. CCGA (Cryptochlorogenic Acid) dose-dependently inhibited LPS-induced production of NO, TNF-α, and IL-6 and blocked iNOS, COX-2, TNF-α, and IL-6 expressions. CCGA also significantly increased the GSH/GSSG ratio and SOD activity and reduced the MDA level. Moreover, CCGA suppressed the nuclear translocation of NF-κB by hindering the phosphorylation of IκB kinase (IKK) and degrading IκB. It also downregulated the phosphorylation of MAPKs^[4].
参考文献

[1] Liu H, Zheng YF, et al. Discovery of Anti-inflammatory Ingredients in Chinese Herbal Formula Kouyanqing Granule based on Relevance Analysis between Chemical Characters and Biological Effects. Sci Rep. 2015 Dec 10;5:18080.
[2] Wang Y, Wen J, et al. Simultaneous determination of neochlorogenic acid, chlorogenic acid, cryptochlorogenic acid and geniposide in rat plasma by UPLC-MS/MS and its application to a pharmacokinetic study after administration of Reduning injection. Biomed Chromatogr. 2015 Jan;29(1):68-74.
[3] Zhou Y. The Protective Effects of Cryptochlorogenic Acid on β-Cells Function in Diabetes in vivo and vitro via Inhibition of Ferroptosis. Diabetes Metab Syndr Obes. 2020 Jun 8;13:1921-1931
[4] Zhao XL, Yu L, Zhang SD, Ping K, Ni HY, Qin XY, Zhao CJ, Wang W, Efferth T, Fu YJ. Cryptochlorogenic acid attenuates LPS-induced inflammatory response and oxidative stress via upregulation of the Nrf2/HO-1 signaling pathway in RAW 264.7 macrophages. Int Immunopharmacol. 2020 Jun;83:106436

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.8224 mL
- 14.1120 mL
- 28.2240 mL
- 5 mM
- 0.5645 mL
- 2.8224 mL
- 5.6448 mL
- 10 mM
- 0.2822 mL
- 1.4112 mL
- 2.8224 mL

技术信息

CAS号

905-99-7

储存条件

粉末: Keep in dark place,Inert atmosphere,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C16H18O9

运输

蓝冰

分子量

354.31

别名

4-Caffeoylquinic acid;4-O-Caffeoylquinic acid;隐绿原酸

溶解度

DMSO	50.0 mg/mL (141.1 mM) warming

动物实验配方

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